Asian Journal of Biology <p style="text-align: justify;">The aim of <strong>Asian Journal of Biology&nbsp;(ISSN: 2456-7124)</strong>&nbsp;is to publish high quality papers (<a href="/index.php/AJOB/general-guideline-for-authors">Click here for Types of paper</a>) with broad areas of Aerobiology, &nbsp;Agriculture, Anatomy, Astrobiology, Biochemistry, Bioengineering, Bioinformatics, Biomathematics or Mathematical Biology, Biomechanics, Biomedical research, Biophysics, Biotechnology, Building biology, Botany, Cell biology, Conservation Biology, Cryobiology, Developmental biology, Food biology, Ecology, Embryology, Entomology, Environmental Biology, Epidemiology, Ethology, Evolutionary Biology, Genetics, Herpetology, Histology, Ichthyology, Integrative biology, Limnology,&nbsp; Mammalogy, Marine Biology, Microbiology, Molecular Biology, Mycology, Neurobiology, Oceanography, Oncology, Ornithology, Population biology, Population ecology, Population genetics, Paleontology, Pathobiology or pathology, Parasitology, Pharmacology, Physiology, Psychobiology, Sociobiology, Structural biology, Virology and&nbsp; Zoology. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal.</p> en-US (Asian Journal of Biology) (Asian Journal of Biology) Wed, 16 Sep 2020 11:41:59 +0000 OJS 60 Anti-Inflammatory Activity of Ethanol Root Extract of Panicum maximum <p><strong>Background:</strong> <em>P</em><em>anicum maximum</em> root is used routinely to treat ailments such as malaria, fever, pains and inflammatory diseases by traditional medicine practitioners.</p> <p><strong>Aim:</strong> The study evaluated the anti-inflammatory effect of <em>P. maximum</em> root so as to validate its uses by practitioners of traditional medicine.</p> <p><strong>Methodology:</strong> The root of <em>P. maximum</em> (dried powdered material) was extracted in ethanol using cold maceration technique. The root crude extract (137 –547 mg/kg) of <em>P. maximum</em> was investigated for anti-inflammatory activity using various experimental models; carrageenan, egg albumin and xylene - induced edema models.</p> <p><strong>Results:</strong> The root extract of <em>P. maximum</em> caused significant (p&lt;0.05 – 0.001) reduction of inflammation induced by the phlogistic agents in a dose-dependent fashion. The recorded anti-inflammatory effects were comparable to those initiated by 100 mg/kg acetyl salicylic acid (ASA, standard drug) used in some of the models here. The anti-inflammatory effect of this plant may be attributed to the phytochemical constituents of the plant.</p> <p><strong>Conclusion:</strong> The findings from this research confirm the ethnomedical use of <em>Panicum maximum</em> root in treating inflammatory conditions.</p> John A. Udobang, Jude E. Okokon, Daniel N. Obot, Utibe A. Edem ##submission.copyrightStatement## Wed, 16 Sep 2020 00:00:00 +0000 Nematocidal Activity on Onchocerca ochengi, Toxicity and Phytochemical Screening of Vernonia perrottetii Sch. Bip. Ex Walp (Asteraceae) Extracts <p>Onchocerciasis is a disease caused by a parasitic nematode <em>Onchocerca volvulus</em> in human.&nbsp; Ivermectin who is the main drug recommended for the treatment of this disease is only effective against the microfilarial stage of the parasite. Reports of emergence of parasite resistance to ivermectin have complicated onchocerciasis treatment and require to discover novel drugs. The objective of the present study was to investigate in <em>vitro</em> anthelmintic properties against the cattle filarial parasite <em>Onchocerca ochengi</em>, a model closely related to <em>Onchocerca volvulus</em>; and evaluate the toxicity <em>(in vivo)</em> of local medicinal plant <em>Vernonia perrottetii. </em>This plant is used as alternative medicine in the treatment of human onchocerciasis in central and coastal regions of Cameroon. Fifteen crude extracts were prepared from various parts of <em>V.</em> <em>perrottetii </em>using three organic solvents (70% ethanol, methanol, methylene chloride) and distilled water. The nematocidal activity was evaluated on adult worms of <em>O. ochengi</em>, worm viability was assessed biochemically using the dimethylthiazol (MTT) formazan assay. Oral toxicity of the promising extract was investigated in mice. The ethanolic extracts of the leaves and roots of <em>V. perrottetii</em> recorded the highest activities against adult male worms (LC<sub>50</sub> of 29.80 μg/mL for leaves and 39.36 μg/mL for root). By contrast, the methanol and aqueous extracts of leaves and roots, of the plant as well as the mixture methylene chloride/methanol extracts. For acute treatment, a single dose of 2000 mg/kg no induced critical behavioral changes or death. In sub- acute treatment, daily oral administration of hydro-ethanolic extracts of leaves at the dose of 250, 500 and 750 mg/kg revealed disturbances in the normal growth of animals as well as liver and kidney alterations. Phytochemical analysis of the active extracts revealed the presence of Polyphenols, tannins, saponins and flavonoids. This study revealed the anti-Onchocerca activities of <em>V. perrottetii</em>, indicating a possible new source for developing a phytomedicine or drug for the treatment of human onchocerciasis.</p> Megnigueu Mimi Elodie, Nveikoueing Francis, Ngatcha Zouakeu Katoucha Sidoine, Djedoubouyom Name Elysee, Kouam Fogue Siméon, Ndjonka Dieudonné ##submission.copyrightStatement## Fri, 25 Sep 2020 00:00:00 +0000 Croton zambesicus Root Extract Exert Laxative Effect in Rats <p><strong>Background: </strong><em>Croton zambesicus </em>Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments.</p> <p><strong>Aim:</strong> The root extract of <em>Croton zambesicus</em> was evaluated for effect on the gastrointestinal tract (GIT).</p> <p><strong>Materials and Methods:</strong> The root extract of <em>C. zambesicus </em>(27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT.</p> <p><strong>Results: </strong>The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied.</p> <p><strong>Conclusion: </strong>The findings of this study show that the root extract of <em>C. zambesicus </em>has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.</p> Jude E. Okokon, Augustine I. L. Bassey, Emmanuel E. Nyong, Utibe A. Edem ##submission.copyrightStatement## Tue, 29 Sep 2020 00:00:00 +0000