Development and Evaluation of Fenoprofen Calcium loaded Proniosomal Gel for Topical Anti-inflammatory activity
Avinash S Gudigennavar
*
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Jayadev N Hiremath
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Anita R Desai
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Prabhu K Halakatti
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Laxman Vijapur
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Somlingesh Shidramshettar
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Sakshi Bhattad
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
Kushal S Tegginamani
Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Proniosomal gel of Fenoprofen calcium is a novel drug delivery system designed to enhance the stability, bioavailability and controlled release of Fenoprofen calcium a non steroidal anti-inflammatory drug used for pain and inflammation management.
Aim: The aim of the work is to formulate and evaluate topical proniosomal gel of Fenoprofen calcium using coacervation-phase separation method, along with varying concentration of cholesterol and surfactant. The work was focused to sustain the release profile of Fenoprofen calcium drug along with overcoming its lower solubility profile.
Place and Duration of Study: Department of Pharmaceutics, BVVS Hanagal Shri Kumareshwar College of Pharmacy Bagalkote, Karnataka, India, between December 2023 and November 2024.
Methodology: Fenoprofen calcium loaded proniosomal gel were prepared by Coacervation and phase separation method. The prepared Fenoprofen calcium loaded proniosomal gels were further characterized for zeta potential, drug content, vesicle size, pH, viscosity, entrapment efficiency, In vitro drug release and In vivo anti-inflammatory study.
Results: All the evaluation parameters shown good results for all the formulations. Vesicle size found to be in micro meter scale, DSC studies confirms formation of double layer, SEM studies shown good powder characteristics, FTIR studies confirms there is no interaction between drug and excipients, Zeta potential confirms the charge on vesicle and its stability, all the formulations shows drug content above 90% and the entrapment efficiency of formulation F1 is been maximum among all the formulations. Diffusion studies shows maximum amount of drug release at the end of 24 hours. Kinetic studies confirms the drug release pattern is been diffusion controlled; gel evaluations shows good rheological property of formulations. In vivo anti-inflammatory studies of optimized formulations F1 shows good results.
Conclusion: Overall, the study confirms that, acute inflammation could be treated efficiently by proniosomal gel, in which nonionic surfactant vesicles are utilized competently to load the drug Fenoprofen and treated the acute inflammation topically in animals, which shows good inflammatory action.
Keywords: Proniosomes, proniosomal gel, Fenoprofen calcium, coacervation-phase separation method, In vitro drug release, In vivo anti-inflammatory study