Croton zambesicus Root Extract Exert Laxative Effect in Rats

Main Article Content

Jude E. Okokon
Augustine I. L. Bassey
Emmanuel E. Nyong
Utibe A. Edem


Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments.

Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT).

Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT.

Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied.

Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.

Croton zambesicus, Purgative, GIT.

Article Details

How to Cite
Okokon, J. E., Bassey, A. I. L., Nyong, E. E., & Edem, U. A. (2020). Croton zambesicus Root Extract Exert Laxative Effect in Rats. Asian Journal of Biology, 10(2), 22-26.
Original Research Article


Adjanohoun EJ, Adjakide V, de Souza S. Contribution to ethnobotanical and floristic studies in Republic of Benin. Agency for Cultural and Technical Cooperation. 1989; 1:245.

Okokon JE, Nwafor PA. Antiplasmodial activity of root extract and fractions of Croton zambesicus. J Ethnopharm. 2009; 121:74-78.

Okokon JE, Nwafor PA. Antiulcer and anticonvulsant activities of Croton zambesicus root extract. Pak J Pharmaceut Sci. 2009;22:384- 390.

Okokon JE, Nwafor PA. Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus. Pak J Pharmaceut Sci. 2010; 23:383-390.

Okokon JE, Nwafor PA, Ekpo E, Okokon P, Udobang J. Antidiabetic and hypolipidemic activities of ethanolic root extract of Croton zambesicus on alloxan induced diabetic rats. Asian J Pharmaceut Res. 2011;1:493 – 499.

Okokon JE, Nwafor PA, Noah K. Nephroprotective effect of Croton zambesicus root extract against gentimicin-induced kidney injury. Asian Pac J Trop Med. 2011;4:969-972.

Okokon JE, Dar A., Choudhary MI. Immunomodulatory, cytotoxic and antileishmanial activities of phytoconstituents of Croton zambesicus Phytopharmacol. 2013;4(1):31 – 40.

Boyom FF, Keumdjio F, Dongmo PM, Ngadjui BT, Amvam-Zollo PH, Menut C, Bessiere JM. Essential oil from Croton zambesicus Muell. Arg. growing in Cameroun. Flav Fragr J. 2002;17:215– 217.

Nwafor PA, Jacks TW, Ekanem AU and Ching FP. Antiulcerogenic and antidiarrhoeal potentials of Pausinystalia macroceras stem-bark in rats.Nigerian Journal of Natural Products and Medicine,2005; 9: 66-70

Shankara S, Sriram N. Laxative effect on methanol extracts of leaves of Basella alba. Intl J Allied Med Sci Clin Res. 2014; 2(4):392-394.

Nwafor PA, Okwuasaba FK. Effect of methanolic extract of Cassia nigricans leaves on gastrointestinal tract. Fitoterapia. 2001;72:206-214.

Yadav S, Kumar P, Shridhar B, Shukla D, Baiga VP, Mani M. Laxative activity of hydroalcoholic leaves extract of Putranjiva roxburghii. J Drug Delivery and Therapeut. 2018;8(4):142-144.

Galvez J, Zarzuelo A, Crespo ME, Lorente MD, Ocente MA, Jimenez J. Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavonoid constituent. Planta Med. 1993;59:333-336.

Yoshio K, Kazuko S, Bunsyo M, Kazunori H, Atsushi I, Yasuhiro K. Relationship between antidiarrhoeal effects of Hange-shashin-To and active components. Phytother Res. 1999;13:468-473.

Rouf AS, Islam MS, Rahman MT. Evaluation of antidiarrhoeal activity of Rumex maritimus roots. J Ethnopharm. 2003;84:307-310.

Vareinshang T, Yadav AK. Antidiarrhoeal activity of Rhus javanica ripen fruit extract in albino mice. Fitoterapia. 2004;75:39-44.

Chatsri D, Sutthasinee P, Watchareewan T, Nateetip K. Barakol Extracted from Cassia siamea stimulates chloride secretion in rat colon. J Pharmacol. Expl Therapeut. 2005; 314:732-734.

Longanga-Otshudi A, Vercruysse A, Foriers A. Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhea in Lomela area, Democratic Republic of Congo (DRC). J Ethnopharm. 2000;71:411-423.