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The study evaluated effects of varying dietary protein levels on growth, protein utilization, survival and yield of the African catfish, Clarias gariepinus using floating net-hapa (1 m x 1 m x 1 m) system. A total of 300 catfish fingerlings (4.50± 0.01 g) were randomly stocked at 20 fish/m3 hapa. Five diets: Diet 1 (40% cp), Diet 2 (42.5% cp), Diet 3 (45% cp), Diet 4 (47.5% cp) and Diet 5 (50% cp) were formulated and fed to triplicate groups for 24 weeks. Growth responses and economic performances of fish harvested under various treatments were evaluated. Results showed that no significant differences (p > 0.05) were observed in metabolic growth rate, percentage survival, total feed intake, cost of feeding and total cost of production in all the treatments. However, significant differences (p < 0.05) existed in specific growth rates, gross profit, profit index and economic conversion ratio. The preferential diet being 42.5% protein, produced the highest mean final weight (946.89 g), specific growth rate (3.21%/day), food conversion ratio (0.27), protein productive value (59.55%) and protein index (5.29 g/day), highest yield (17,850 kg/hapa), gross profit (774/hapa) and economic conversion ratio (58.98). From these results, it was concluded that C. gariepinus would grow best in floating net-hapa when fed diets containing 42.5% protein.