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This study was to isolate and identify antioxidant and anticancer compounds from extracts of bark and leaf of Terminalia nigrovenulosa. The EtOAc fraction of bark and n-BuOH fraction of leaf exhibited the highest DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) radical scavenging activity. Nuclear magnetic resonance (NMR) and mass spectra results showed that gallic acid, ethyl gallate, ellagic acid, catechin and luteolin isolated in EtOAc and n-BuOH fractions were the main components possessed DPPH radical scavenging activity. These fractions and their isolated compounds reduced human fibrosarcoma (HT1080) cell viability in a dose-dependent manner. In addition, these fractions and their isolated compounds significantly increased caspase-3 activity. Therefore, the reduction of cell viability might be due to the induction of apoptosis via caspase-3 pathway. These findings could be useful for the development of new chemotherapeutic agents for the treatment of malignant cancers from T. nigrovenulosa extracts and isolated compounds.