Effect of Hypoxia on the Induction of Premature Cellular Senescence in the Cells of Periodontium during Orthodontic Tooth Loading

Main Article Content

Luay Thanoon Younis
Faisal Ismail Elsayed Bahnasi
Aida Nur Ashikin Abd Rahman
Mohamed Ibrahim Abu Hassan

Abstract

During orthodontic treatment, application of forces to move the teeth within the dento-alveolar complex is associated with structural and biological tissues changes. One of the main changes is hypoxia which is due to the compression of blood vessels resulting in insufficient oxygenation of the tissues. On orthodontic loading, hypoxia causes irreversible cell cycle arrest (or so called cellular senescence) and apoptosis of the tissue cells around the teeth especially on the compression zone. Excessive hypoxia, in turn leads to a massive, an inevitable and detrimental destruction of tissues supporting the tooth such as remarkable root resorption. This mini-review is highlighting the effect of orthodontic force in inducing a local hypoxic environment and its consequences in causing cells death of the periodontal cells.

Keywords:
Periodontal ligament, hypoxia, cellular senescence, tooth movement

Article Details

How to Cite
Younis, L. T., Bahnasi, F. I. E., Rahman, A. N. A. A., & Hassan, M. I. A. (2019). Effect of Hypoxia on the Induction of Premature Cellular Senescence in the Cells of Periodontium during Orthodontic Tooth Loading. Asian Journal of Biology, 8(3), 1-5. https://doi.org/10.9734/ajob/2019/v8i330062
Section
Minireview Article

References

Cunningham S, Horrocks E, Hunt N, Jones S, Moseley H, Noar J, et al. ABC or oral health. Improving Occlusion and Orofacial Aesthetics: Orthodontics. Bmj. 2000;321 (7256):288-90.

McCormack SW, Witzel U, Watson PJ, Fagan MJ, Groning F. The biomechanical function of periodontal ligament fibres in orthodontic tooth movement. PLoS One. 2014;9(7):e102387.

Li Y, Jacox LA, Little SH, Ko CC. Orthodontic tooth movement: The biology and clinical implications. The Kaohsiung Journal of Medical Sciences. 2018;34(4): 207-14.

Carreau A, El Hafny-Rahbi B, Matejuk A, Grillon C, Kieda C. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med. 2011;15(6):1239-53.

Kifune T, Ito H, Ishiyama M, Iwasa S, Takei H, Hasegawa T, et al. Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts. J Oral Sci. 2018;60 (4):519-25.

Niklas A, Proff P, Gosau M, Romer P. The role of hypoxia in orthodontic tooth movement. Int J Dent. 2013;841840.

Wei F, Yang S, Xu H, Guo Q, Li Q, Hu L, et al. Expression and function of hypoxia inducible factor-1alpha and vascular endothelial growth factor in pulp tissue of teeth under orthodontic movement. Mediators of inflammation. 2015;215761.

Greer SN, Metcalf JL, Wang Y, Ohh M. The updated biology of hypoxia-inducible factor. Embo J. 2012;31(11):2448-60.

Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. Embo J. 2000;19(16):4298-309.

Salceda S, Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem. 1997;272(36):22642-7.

Krock BL, Skuli N, Simon MC. Hypoxia-induced angiogenesis: Good and evil. Genes Cancer. 2011;2(12):1117-33.

Liu LL, Li D, He YL, Zhou YZ, Gong SH, Wu LY, et al. miR-210 protects renal cell against hypoxia-induced apoptosis by targeting HIF-1 alpha. Mol Med. 2017;23: 258-71.

Zhang X, Chen D, Zheng J, Deng L, Chen Z, Ling J, et al. Effect of microRNA-21 on hypoxia-inducible factor-1alpha in orthodontic tooth movement and human periodontal ligament cells under hypoxia. Exp Ther Med. 2019;17(4):2830-6.

Huang Y, Zhang Y, Li X, Liu H, Yang Q, Jia L, et al. The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force. European Journal of Orthodontics. 2019;41 (4):333-42.

Bae WJ, Park JS, Kang SK, Kwon IK, Kim EC. Effects of melatonin and Its underlying mechanism on ethanol-stimulated senescence and osteoclastic differentiation in human periodontal ligament cells and cementoblasts. Int J Mol Sci. 2018; 19(6).

Younis LT, Abu Hassan MI, Taiyeb Ali TB, Bustami TJ. 3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. Asian Journal of Pharmaceutical Sciences. 2018;13(4):317-25.

Borodkina AV, Deryabin PI, Giukova AA, Nikolsky NN. Social life of senescent cells: What Is SASP and Why study it? Acta Naturae. 2018;10(1):4-14.

Regulski MJ. Cellular Senescence: What, Why and How. Wounds. 2017;29(6):168-74.

Lujambio A. To clear, or not to clear (Senescent cells)? That is the question. Bioessays. 2016;38(Suppl 1):S56-64.

Bishayee K, Paul A, Ghosh S, Sikdar S, Mukherjee A, Biswas R, et al. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Mol Cell Biochem. 2013;382(1-2):173-83.

Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169 (1):132-47.e16.

Matsuzawa H, Toriya N, Nakao Y, Konno-Nagasaka M, Arakawa T, Okayama M, et al. Cementocyte cell death occurs in rat cellular cementum during orthodontic tooth movement. Angle Orthod. 2017;87(3):416-22.

Minato Y, Yamaguchi M, Shimizu M, Kikuta J, Hikida T, Hikida M, et al. Effect of caspases and RANKL induced by heavy force in orthodontic root resorption. Korean J Orthod. 2018;48(4): 253-61.

Funakoshi M, Yamaguchi M, Asano M, Fujita S, Kasai K. Effect of Compression Force on Apoptosis in Human Periodontal Ligament Cells. Journal of Hard Tissue Biology. 2013;22(1):41-50.

Zhong W, Xu C, Zhang F, Jiang X, Zhang X, Ye D. Cyclic stretching force-induced early apoptosis in human periodontal ligament cells. Oral Dis. 2008;14(3): 270-6.

Von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci. 2000;908: 99-110.

Von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27 (7):339-44.

Kepinska M, Szyller J, Milnerowicz H. The influence of oxidative stress induced by iron on telomere length. Environ Toxicol Pharmacol. 2015;40(3):931-5.

d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003;426(6963):194-8.

Moin S, Kalajzic Z, Utreja A, Nihara J, Wadhwa S, Uribe F, et al. Osteocyte death during orthodontic tooth movement in mice. Angle Orthod. 2014;84(6):1086-92.

Elmore S. Apoptosis: A review of programmed cell death. Toxicol Pathol. 2007;35(4):495-516.

Kremer AE, Rust C, Eichhorn P, Beuers U, Holdenrieder S. Immune-mediated liver diseases: Programmed cell death ligands and circulating apoptotic markers. Expert Rev Mol Diagn. 2009;9(2): 139-56.

Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D'Orazi G. Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany NY). 2016;8(4): 603-19.

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 2014;15(11):1139-53.

Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 2008;15(2):243-50.

Wise GE, King GJ. Mechanisms of tooth eruption and orthodontic tooth movement. Journal of Dental Research. 2008;87(5): 414-34.

Von Bohl M, Kuijpers-Jagtman AM. Hyalinization during orthodontic tooth movement: A systematic review on tissue reactions. European Journal of Orthodontics. 2009;31(1):30-6.

Suttorp CM, Xie R, Lundvig DM, Kuijpers-Jagtman AM, Uijttenboogaart JT, Van Rheden R, et al. Orthodontic forces induce the cytoprotective enzyme heme oxygenase-1 in rats. Front Physiol. 2016;7: 283.

Cardaropoli D, Gaveglio L. The influence of orthodontic movement on periodontal tissues level. Seminars in Orthodontics. 2007;13(4):234 - 45.

Rody WJ. Jr, King GJ, Gu G. Osteoclast recruitment to sites of compression in orthodontic tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics: Official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 2001; 120(5):477-89.